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Gmeiner, William

One or more keywords matched the following items that are connected to Gmeiner, William

Item Type	Name
Academic Article	Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Academic Article	Novel chemical strategies for thymidylate synthase inhibition.
Academic Article	Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Academic Article	Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif.
Academic Article	Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA.
Academic Article	NMR spectroscopy as a tool to investigate the structural basis of anticancer drugs.
Academic Article	Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins.
Academic Article	A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Academic Article	Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article	Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP.
Academic Article	Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro.
Concept	Antineoplastic Agents
Concept	Antineoplastic Agents, Phytogenic
Academic Article	Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity.
Academic Article	Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.
Academic Article	Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway.
Academic Article	The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence.
Academic Article	Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides.
Academic Article	Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug Screening.
Academic Article	Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.

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Antineoplastic Agents